The easiest way to beat the most common defense in Madden 25 (2 man under) is by using the deep out route which is also known as the smart routed out route.
The video below provides an easy tutorial on how to do it which works on PS4 and XBOX One as well as the PS3 and XBOX 360.
Madden 25 On PS4 and XBOX One How To Beat 2 Man Under Defense
Formation: Any Non-compressed or tight formation
Play: Any passing play
- Hot route either of your outside wide receivers to a deep out
- Bullet pass it to your receiver right when he makes his break to the sideline