I have no trouble beating Fag D usually. If running the ball is an option, do it. Otherwise I've had people send 1 or even 0 rushers at me and drop everyone into coverage. Then you just have to ignore your internal clock as QB and wait for someone to get open. Can take a while sometimes but they pretty much always do, especially if you have a lot of field to work with.
I played against the 49ers alot along with packers, texans, skins, hawks but I just roll with a good team too usually pats or falcons